NKTR-0165

NKTR-0165

Our Tumor necrosis factor (TNF) receptor type II (TNFR2) agonist asset is a unique bivalent antibody molecule developed by leveraging Biolojic’s proprietary technology to selectively stimulate TNFR2 receptor activity, without modulation of the TNFR1 signaling. TNFR2 signaling has been shown to be an important gatekeeper of inflammation and its absence or deficit is associated with a broad range of autoimmune diseases. TNFR-2 is highly expressed on T regulatory cells (Tregs), neuronal cells and endothelial cells and has been shown to potentiate the suppressive effects and overall functional properties of Tregs. This novel first-in-class compound has the potential to modulate acute exacerbations and chronic trajectory of a number of autoimmune diseases.